Dr. Talat Waseem

FRCS England, FRCS (GenSurg), FACS, FCPS;
MCh (OPBS-UK); MME 
Former Postdoctoral Fellow in Surgical Research, Brigham & Womens Hospital, Harvard Medical School (Boston-US)

General Secretary Pakistan Endocrine & Thyroid Surgeons Association (PETSA- www.petsa.net);

Editor In Chief Archives of Surgical Research (www.archivessr.com);

Associate Professor of Surgery at Shalamar Medical & Dental College, Lahore.

Dr. Talat Waseem has a special interest in Endocrine Surgery (Thyroid, Parathyroid, Adrenal), Surgical Oncology, Head & Neck and Breast Surgery. Surgical Education and Research are additional interests.

He has been previously trained at Brigham & Women's Hospital, Harvard Medical School under Prof Stanley W Ashley, at University College Cork, and by legendary Prof Khwaja Muhammad Azim. Other salient mentors include Michael J Zinner, Malcolm Robinson, Edward E Whang, Prof Paul Redmond, Jennifer Smith, Steven Thrush, Harun E Thomas, Sue Downe.

 

Dr. Talat Waseem currently holds the position of Associate Professor of Surgery in the Division of Surgical Oncology and Endocrine Surgery at Shalamar Medical & Dental College Lahore. He primarily deals with the surgery of cancer and endocrine glands (thyroid, parathyroid, and adrenals). He has had more than 5000 surgical procedures during the last 5 years under his log which include thyroidectomies, radical neck dissections, pancreatectomies, esophagectomies, and many more. 

Mr. Waseem is a leading general surgeon and researcher who has extensively worked on discovering important roles of ghrelin in the gastrointestinal tract. His work has provided significant insights into ghrelin-linked intestinal cell proliferation, apoptosis, and physiological function during inflammation. Moreover, he has discovered the role of ghrelin in gastrointestinal and pancreatic malignancy.

Dr. Waseem continues to work on ghrelin and many other important surgical problems. Under his leadership, Department has designed many important instruments and has answered critical scientific questions in surgery.  He along with his team in Shalamar Surgical Research Initiative has developed many tools like PreODIT to measure the difficulty in thyroidectomy, Shalamar Online Learning Experience Measure (SOLEM), SOREEM, Curriculum Compass, etc. Apart from ghrelin, his research has mainly focused on thyroid/ parathyroid surgery, surgical education, artificial intelligence, pancreatic malignancy, and gastrointestinal physiology.

Dr Waseem has published in numerous peer-reviewed international journals which can be accessed through the National Library of Medicine's database (PubMed).

He has previously published in various journals including Journal of American College of Surgeons, Surgery, Surgery Today, Peptides, Cancer Research, Clinical Cancer Research, ANZ Journal of Surgery, JCPSP, European Journal of Cardiothoracic Surgery, BBRC, etc.

 

He has been reviewing for various journals including Peptides, Journal of Digestive Diseases, BBRC, Surgery, Surgical Oncology, and World Journal of Surgery.

He has previously presented his research work at various prestigious forums including the Annual Meeting of the American College of Surgeons, American College of Gastroenterology, Society of University Surgeons, and 2009 International Symposium on Ghrelin.

His publications may be retrieved from ResearchGate or Google Scholar

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Research Publications​

Here is a brief list of salient publications:

1.        Duxbury MS, Waseem T, Ito H, et al. Ghrelin promotes pancreatic adenocarcinoma cellular proliferation and invasiveness. Biochem Biophys Res Commun. 2003;309(2):464-468. Accessed February 3, 2018. http://www.ncbi.nlm.nih.gov/pubmed/12951072

2.        Duxbury MS, Waseem T, Ito H, et al. Ghrelin promotes pancreatic adenocarcinoma cellular proliferation and invasiveness. Biochem Biophys Res Commun. 2003;309(2). doi:10.1016/j.bbrc.2003.08.024

3.        Duxbury MSMS, Ito H, Benoit E, Waseem T, Ashley SWSW, Whang EEE. No Title. 2004;64(11):3987-3993. doi:10.1158/0008-5472.CAN-04-0424

4.        Duxbury MS, Ito H, Benoit E, Waseem T, Ashley SW, Whang EE. Experimental Therapeutics, Molecular Targets, and Chemical Biology-A Novel Role for Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 as a Determinant of Gemcitabine Chemoresistance in. Cancer Res. 2004;64(11):3987-3993.

5.        Waseem T, Duxbury MS, Ito H, et al. Ghrelin: a novel humoral mediator of intestinal adaptation. In: Gastroenterology. Vol 126. WB SAUNDERS CO INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA; 2004:A136-A136.

6.        Waseem T, Duxbury M, Ito H, et al. Ghrelin ameliorates TNF-a induced anti-proliferative and pro-apoptotic effects and promotes intestinal epithelial restitution. J Am Coll Surg. 2004;199(3):16.

7.        Duxbury MS, Ito H, Benoit E, Waseem T, Ashley SW, Whang EE. A novel role for carcinoembryonic antigen-related cell adhesion molecule 6 as a determinant of gemcitabine chemoresistance in pancreatic adenocarcinoma cells. Cancer Res. 2004;64(11). doi:10.1158/0008-5472.CAN-04-0424

8.        Duxbury MS, Ito H, Benoit E, Waseem T, Ashley SW, Whang EE. RNA interference demonstrates a novel role for integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell gemcitabine chemoresistance. Clin Cancer Res. 2005;11(9):3433-3438. doi:10.1158/1078-0432.CCR-04-1510

9.        Waseem T. Technologic advances in robotic surgery. J Coll Physicians Surg Pakistan. 2005;15(9).

10.      Waseem T. RNA interference: A potential revolution in disease therapy. J Coll Physicians Surg Pakistan. 2006;16(7).

11.      Waseem T, Javaid-ur-Rehman, Sabir N-U-D, Hussain S, Amir E, Arif S. Rare association: ileocaeco-colic intussusception secondary to mucinous cystadenoma of the appendix in an adult. ANZ J Surg. 2007;77(11):1021-1022. doi:10.1111/j.1445-2197.2007.04303.x

12.      Waseem T, Mogensen KM, Lautz DB, Robinson MK. Pathophysiology of obesity: why surgery remains the most effective treatment. Obes Surg. 2007;17(10):1389-1398. doi:10.1007/s11695-007-9220-1

13.      Waseem T, Javaid-Ur-Rehman, Sabir N-U-D, Hussain S, Amir E, Arif S. Rare association: Ileocaeco-colic intussusception secondary to mucinous cystadenoma of the appendix in an adult. ANZ J Surg. 2007;77(11). doi:10.1111/j.1445-2197.2007.04303.x

14.      Waseem T, Mogensen KM, Lautz DB, Robinson MK. Pathophysiology of obesity: Why surgery remains the most effective treatment. Obes Surg. 2007;17(10). doi:10.1007/s11695-007-9220-1

15.      Talat W. Exogenous ghrelin modulates release of proand anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways. Surgery. 2008;143(3):334-342.

16.      Waseem T, Duxbury M, Ito H, et al. Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways. Surgery. 2008;143(3):334-342. doi:10.1016/j.surg.2007.09.039

17.      Waseem T, others. Intestinal tissue engineering: Where do we stand? Surg Today. 2008;38(6):484-486.

18.      Waseem T, Duxbury M, Ito H, Ashley SW, Robinson MK. Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways. Surgery. 2008;143(3):334-342. doi:10.1016/j.surg.2007.09.039

19.      Waseem T, Javaid-Ur-Rehman, Ahmad F, Azam M, Qureshi MA. Role of ghrelin axis in colorectal cancer: a novel association. Peptides. 2008;29(8):1369-1376. doi:10.1016/j.peptides.2008.03.020

20.      Waseem T, Duxbury M, Ito H, Ashley SW, Robinson MK. Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways. Surgery. 2008;143(3). doi:10.1016/j.surg.2007.09.039

21.      Javaid-Ur-Rehman, Waseem T. Intestinal tissue engineering: Where do we stand? Surg Today. 2008;38(6). doi:10.1007/s00595-007-3671-9

22.      Waseem T. Commentary: Ghrelin’s role in gastrointestinal tract cancer. Surg Oncol. 2009;19(1):e1-e1.

23.      Nabi MSMS, Waseem T, Sultan I, Tarif N. No Title. 2010;37(5):1224. doi:10.1016/j.ejcts.2009.12.003

24.      Nabi MS, Waseem T, Tarif N, Chima KK. Pulmonary hydatid disease: is capitonnage mandatory following cystotomy? Int J Surg. 2010;8(5):373-376. Accessed February 3, 2018. http://www.ncbi.nlm.nih.gov/pubmed/20681056

25.      Nabi MS, Waseem T. Pulmonary hydatid disease: what is the optimal surgical strategy? Int J Surg. 2010;8(8):612-616. doi:10.1016/j.ijsu.2010.08.002

26.      Nabi MS, Waseem T, Sultan I, Tarif N. A large pulmonary arteriovenous malformation: a classical scenario. Eur J Cardio-thoracic Surg. 2010;37(5). doi:10.1016/j.ejcts.2009.12.003

27.      Nabi MS, Waseem T, Tarif N, Chima KK. Pulmonary hydatid disease: Is capitonnage mandatory following cystotomy? Int J Surg. 2010;8(5). doi:10.1016/j.ijsu.2010.05.007

28.      Nabi MS, Waseem T. Pulmonary hydatid disease: What is the optimal surgical strategy? Int J Surg. 2010;8(8). doi:10.1016/j.ijsu.2010.08.002

29.      Waseem T, Swati W, Sheikh A, Murchan P. Is Laparoscopic Peritoneal Lavage an Acceptable Alternative to Hartmann’s Procedure for Diverticular Perforation? A Systematic Review. J Curr Surg. 2012;2(4-5):133-140.

30.      NABI* MS, WASEEM T, al NT et. Intrathoracic Carcinoids: A 7-Year Tertiary Care Level Experience. J Fatima Jinnah Med Coll. 2012;6(3):19-22.

31.      Waseem T, Duxbury M, Ashley SWSW, Robinson MKMK. No Title. Peptides. 2014;52:113-121. doi:10.1016/j.peptides.2013.11.021

32.      Waseem T, Duxbury M, Ashley SW, Robinson MK. Ghrelin promotes intestinal epithelial cell proliferation through PI3K/Akt pathway and EGFR trans-activation both converging to ERK 1/2 phosphorylation. Peptides. 2014;52:113-121. doi:10.1016/j.peptides.2013.11.021

33.      Azim A, Azim A, Waseem T, Azim KM. Kimura’s Disease: A Rare Clinical Entity for A Head & Neck Surgeon. Am J Cancer Case Reports. 2014;2(2):73-78.

34.      Waseem T, Duxbury M, Ashley SW, Robinson MK. Ghrelin promotes intestinal epithelial cell proliferation through PI3K/Akt pathway and EGFR trans-activation both converging to ERK 1/2 phosphorylation. Peptides. 2014;52. doi:10.1016/j.peptides.2013.11.021

35.      Waseem T, Azim A, Ashraf MH, Azim KM. Roux-en-Y augmented gastric advancement: An alternative technique for concurrent esophageal and pyloric stenosis secondary to corrosive intake. World J Gastrointest Surg. 2016;8(12):766-769. doi:10.4240/wjgs.v8.i12.766

36.      Ashraf MH, Azim A, Waseem T, Azim KM. A Rare Salivary Duct Parotid Tumor; Management By Total Conservative Parotidectomy And Free Flap Transfer. Prof Med J. 2016;23(9):1163-1166.

37.      Ashraf A, Azim A, Azim KM, Waseem T. Papillary Thyroid Microcarcinoma Presenting as Horner’s Syndrome: A Novel Clinical Presentation. Am J Cancer Case Reports. 2016;4(1):38-43.

38.      Azim A, Altaf R, Waseem T, Ashraf MH, Azim KM. Xanthogranulomatous Cholecystitis Mimicking as Gallbladder Carcinoma:A Caution for Hepatobiliary Surgeon. Am J Cancer Case Reports. 2016;4(2):101-105.

39.      Arif S, Waseem T, Javaid-ur-Rehman Ashraf D, Ahmad F. Stapled Hemorrhoidectomy; Is It Really Superior To Conventional Hemorrhoidectomy? A Longterm Analysis. Prof Med J. 2016;23(12):1505-1512.

40.      Azim A, Mir F, Waseem T, Azim M K. Non-Alpine Epithelioid Angiosarcoma of Thyroid Gland: A Rare Clinical Scenario. Am J Cancer Case Reports. 2016;4(2):152-155.

41.      Waseem T, Azim A, Ashraf MH, Azim KM. Roux-en-Y augmented gastric advancement (RAGA): An alternative technique for concurrent esophageal and pyloric stenosis secondary to corrosive intake. World J Gastrointest Surg. 2016;8(12):766-769.

42.      Arif S, Waseem T, Ashraf J-U-R. Prognostic predictive value of Mannheim peritonitis index in secondary peritonitis: A prospective study. Pakistan J Med Heal Sci. 2016;10(3).

43.      Waseem T, Azim KM. Preoperative Difficulty Index for Thyroidectomy (PreoDIT): A Novel Preoperative Roadmap. J Am Coll Surg. 2019;229(4):e104.

44.      Waseem T, Ashraf MH, Rabbani S, Shoaib H, Khan RA. Evolving role of social networking sites in undergraduate surgical education: student perspective. Pak J Med Heal Sci. 2019;13:894-899.

45.      Saeed A, Nousherwani MD, Waseem T, Zafar Z, Mehmood Z, Usman J. Impact of Personal Protective Equipment on Surgeon’s Performance during COVID-19 Crisis: Qualitative Exploration of Challenges and Solutions. Arch Surg Res. 2020;1(2):28-35.

46.      Waseem T, Ahmad SZ, Zafar Z, Ashraf MH, Azim KM. How to Decide for Drain Placement During Thyroidectomy? Qualitative Exploration to Formulation of a Decision Tree. Arch Surg Res. 2020;1(3):5-11.

47.      Ahmed AS, Ahmed SZ, Ahmed M, Waseem T. Emerging Trends in Managing Central Breast DCIS in Era of Oncoplastic Surgery: Where Do We Stand? Arch Surg Res. 2020;1(2):20-27.

48.      Waseem T. Stomach or Colon for Esophageal Replacement? What Prof Haider Thought! Arch Surg Res. 2020;1(3):1-2.

49.      Ashraf H, Waseem T. The Rising Need for Endocrine Surgery Fellowship in Pakistan. Arch Surg Res. 2020;1(3):2-4.

50.      Waseem T, Ahmed SZ, Baig H, Ashraf MH, Azim A, Azim KM. Truncal vs Branch Ligation of Inferior Thyroid Arteries in Total Thyroidectomy: Does It Affect Postoperative Hypoparathyroidism? Otolaryngol Neck Surg. Published online 2020:0194599820957283.

51.      Ahmad SZ, Waseem T, Zafar Z, Abid M, Azim KM. Impact of Branch vs. Truncal Ligation of Inferior Thyroid Arteries on Post-Thyroidectomy Hypocalcaemia: A Meta-Analysis of Controlled Trials. Arch Surg Res. 2020;1(1):8-17.

52.      Ahmed SZ, Zafar Z, Waseem T, Rafiq F. To Drain or Not to Drain in Thyroidectomy: A Meta-analysis of Outcomes. Arch Surg Res. 2020;1(2):6-17.

53.      Zahara FT, Zafar Z, Waseem T, Shoaib H. Quality Assurance Of Online Surgical Learning Process: Development and Validation of Shalamar Online Learning Experience Measure (SOLEM). Arch Surg Res. 2020;1(1):22-32.

54.      Waseem T, Munir Baig H, Yasmin R, Ahmad Khan R. Exploring Operating Room-Based Student Learning Experience: Perils & Pitfalls? A Narrative Literature Review. Arch Surg Res. 2020;1(1):38-46.

55.      Waseem T, Azim KM. Preoperative Difficulty Index for Thyroidectomy (PreODIT): A Novel, Reliable, Content Valid, and Valuable Tool. J Am Coll Surg. 2020;231(4):e115-e116.

56.      Ashraf H, Shafiq MM, Ahmed SZ, Waseem T. Pre-Operative Parathyroid Gland Localization in Primary Hyperparathyroidism: A Systematic Literature Review. Arch Surg Res. 2020;1(1):41-51.

57.      Arif S, Waseem T. Managing Cognitive Retention of Surgical Graduate with Improved Techniques: Lessons from Cognitive Psychology. Arch Surg Res. 2020;1(2):54-57.

58.      Jamil F, Farooqi S, Waseem T. Why the Art of Clinician Is Dying? Opinions & Judgements: A Systematic Review. Arch Surg Res. 2020;1(2):58-63.

59.      Ahmed AS, Ahmed SZ, Zaib N, Waseem T. Evolving Management Options for Breast Cancer in Era of Oncoplastic and Reconstructive Breast Surgery: Where Do We Stand? Arch Surg Res. 2020;1(1):59-65.

60.       Hussain Z, Zahid R, Waseem T. Applications of Radiomics in Breast Surgery. Arch Surg Res. 2020;1(3):24-27.

 

Research-gate Profile